On the performance of routing algorithms in wormhole-switched multicomputer networks

This paper presents a comparative performance study of adaptive and deterministic routing algorithms in wormhole-switched hypercubes and investigates the performance vicissitudes of these routing schemes under a variety of network operating conditions. Despite the previously reported results, our results show that the adaptive routing does not consistently outperform the deterministic routing even for high dimensional networks. In fact, it appears that the superiority of adaptive routing is highly dependent to the broadcast traffic rate generated at each node and it begins to deteriorate by growing the broadcast rate of generated message

A performance model of communication in the quarc NoC

Networks on-chip (NoC) emerged as a promising communication medium for future MPSoC development. To serve this purpose, the NoCs have to be able to efficiently exchange all types of traffic including the collective communications at a reasonable cost. The Quarc NoC is introduced as a NOC which is highly efficient in performing collective communication operations such as broadcast and multicast. This paper presents an introduction to the Quarc scheme and an analytical model to compute the average message latency in the architecture. To validate the model we compare the model latency prediction against the results obtained from discrete-event simulations

Quarc: a novel network-on-chip architecture

This paper introduces the Quarc NoC, a novel NoC architecture inspired by the Spidergon NoC. The Quarc scheme significantly outperforms the Spidergon NoC through balancing the traffic which is the result of the modifications applied to the topology and the routing elements.The proposed architecture is highly efficient in performing collective communication operations including broadcast and multicast. We present the topology, routing discipline and switch architecture for the Quarc NoC and demonstrate the performance with the results obtained from discrete event simulations

Fuzzy based load and energy aware multipath routing for mobile ad hoc networks

Routing is a challenging task in Mobile Ad hoc Networks (MANET) due to their dynamic topology and lack of central administration. As a consequence of un-predictable topology changes of such networks, routing protocols employed need to accurately capture the delay, load, available bandwidth and residual node energy at various locations of the network for effective energy and load balancing. This paper presents a fuzzy logic based scheme that ensures delay, load and energy aware routing to avoid congestion and minimise end-to-end delay in MANETs. In the proposed approach, forwarding delay, average load, available bandwidth and residual battery energy at a mobile node are given as inputs to a fuzzy inference engine to determine the traffic distribution possibility from that node based on the given fuzzy rules. Based on the output from the fuzzy system, traffic is distributed over fail-safe multiple routes to reduce the load at a congested node. Through simulation results, we show that our approach reduces end-to-end delay, packet drop and average energy consumption and increases packet delivery ratio for constant bit rate (CBR) traffic when compared with the popular Ad hoc On-demand Multipath Distance Vector (AOMDV) routing protocol

An application of association rule mining to extract risk pattern for type 2 diabetes using tehran lipid and glucose study database

Background: Type 2 diabetes, common and serious global health concern, had an estimated worldwide prevalence of 366 million in 2011, which is expected to rise to 552 million people, by 2030, unless urgent action is taken. Objectives: The aim of this study was to identify risk patterns for type 2 diabetes incidence using association rule mining (ARM). Patients and Methods: A population of 6647 individuals without diabetes, aged � 20 years at inclusion, was followed for 10-12 years, to analyze risk patterns for diabetes occurrence. Study variables included demographic and anthropometric characteristics, smoking status, medical and drug history and laboratory measures. Results: In the case of women, the results showed that impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), in combination with body mass index (BMI) � 30 kg/m2, family history of diabetes, wrist circumference > 16.5 cm and waist to height � 0.5 can increase the risk for developing diabetes. For men, a combination of IGT, IFG, length of stay in the city (> 40 years), central obesity, total cholesterol to high density lipoprotein ratio � 5.3, low physical activity, chronic kidney disease and wrist circumference > 18.5 cm were identified as risk patterns for diabetes occurrence. Conclusions: Our study showed that ARM is a useful approach in determining which combinations of variables or predictors occur together frequently, in people who will develop diabetes. The ARM focuses on joint exposure to different combinations of risk factors, and not the predictors alone. © 2015, Research Institute For Endocrine Sciences and Iran Endocrine Society

Decision tree-based modelling for identification of potential interactions between type 2 diabetes risk factors: A decade follow-up in a Middle East prospective cohort study

Objective: The current study was undertaken for use of the decision tree (DT) method for development of different prediction models for incidence of type 2 diabetes (T2D) and for exploring interactions between predictor variables in those models. Design: Prospective cohort study. Setting: Tehran Lipid and Glucose Study (TLGS). Methods: A total of 6647 participants (43.4 men) aged >20 years, without T2D at baselines ((1999- 2001) and (2002-2005)), were followed until 2012. 2 series of models (with and without 2-hour postchallenge plasma glucose (2h-PCPG)) were developed using 3 types of DT algorithms. The performances of the models were assessed using sensitivity, specificity, area under the ROC curve (AUC), geometric mean (G-Mean) and F-Measure. Primary outcome measure: T2D was primary outcome which defined if fasting plasma glucose (FPG) was �7 mmol/L or if the 2h-PCPG was �11.1 mmol/L or if the participant was taking antidiabetic medication. Results: During a median follow-up of 9.5 years, 729 new cases of T2D were identified. The Quick Unbiased Efficient Statistical Tree (QUEST) algorithm had the highest sensitivity and G-Mean among all the models for men and women. The models that included 2h-PCPG had sensitivity and G-Mean of (78 and 0.75) and (78 and 0.78) for men and women, respectively. Both models achieved good discrimination power with AUC above 0.78. FPG, 2h-PCPG, waist-toheight ratio (WHtR) and mean arterial blood pressure (MAP) were the most important factors to incidence of T2D in both genders. Among men, those with an FPG�4.9 mmol/L and 2h-PCPG�7.7 mmol/L had the lowest risk, and those with an FPG>5.3 mmol/L and 2h-PCPG>4.4 mmol/L had the highest risk for T2D incidence. In women, those with an FPG�5.2 mmol/L and WHtR�0.55 had the lowest risk, and those with an FPG>5.2 mmol/L and WHtR>0.56 had the highest risk for T2D incidence. Conclusions: Our study emphasises the utility of DT for exploring interactions between predictor variables

Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas

Neuropilins (NRP) are cell surface receptors for VEGF and SEMA3 family members. The role of NRP in neurons and endothelial cells has been investigated, but the expression and role of NRP in epithelial cells is much less clear. Herein, the expression and localization of neuropilin 1 (NRP1) was investigated in human and mouse skin and squamous cell carcinomas (SCC). Results indicated that NRP1 mRNA and protein was expressed in the suprabasal epithelial layers of skin sections. NRP1 staining did not overlap with that of keratin 14 (K14) or proliferating cell nuclear antigen, but did colocalize with staining for keratin 1, indicating that differentiated keratinocytes express NRP1. Similar to the expression of NRP1, VEGF-A was expressed in suprabasal epithelial cells, whereas Nrp2 and VEGFR2 were not detectable in the epidermis. The expression of NRP1 correlated with a high degree of differentiation in human SCC specimens, human SCC xenografts, and mouse K14-HPV16 transgenic SCC. UVB irradiation of mouse skin induced Nrp1 upregulation. In vitro, Nrp1 was upregulated in primary keratinocytes in response to differentiating media or EGF-family growth factors. In conclusion, the expression of NRP1 is regulated in the skin and is selectively produced in differentiated epithelial cells. NRP1 may function as a reservoir to sequester VEGF ligand within the epithelial compartment, thereby modulating its bioactivity

Active Flow Control of Lifting Surface With Flap-Current Activities and Future Directions

The main objective is to develop effective control strategies for separation control of an airfoil with a single hinge flap. The specific objectives are: Develop an active control architecture for flow control around an airfoil with flap. Design, fabricate, a wind tunnel test of a high lift wing (with flap) with integrated actuators and sensors. Design, development and fabrication of synthetic jet actuators. Develop appropriate control strategy for application to the airfoil. Wind tunnel testing of the high lift wing at various angles of attack and flap positions with closed loop control

Parallel In Vivo and In Vitro Melanoma RNAi Dropout Screens Reveal Synthetic Lethality between Hypoxia and DNA Damage Response Inhibition

SummaryTo identify factors preferentially necessary for driving tumor expansion, we performed parallel in vitro and in vivo negative-selection short hairpin RNA (shRNA) screens. Melanoma cells harboring shRNAs targeting several DNA damage response (DDR) kinases had a greater selective disadvantage in vivo than in vitro, indicating an essential contribution of these factors during tumor expansion. In growing tumors, DDR kinases were activated following hypoxia. Correspondingly, depletion or pharmacologic inhibition of DDR kinases was toxic to melanoma cells, including those that were resistant to BRAF inhibitor, and this could be enhanced by angiogenesis blockade. These results reveal that hypoxia sensitizes melanomas to targeted inhibition of the DDR and illustrate the utility of in vivo shRNA dropout screens for the identification of pharmacologically tractable targets

Computational Cancer Biology: An Evolutionary Perspective

ISSN:1553-734XISSN:1553-735